Extended Data Fig. 5: Impact of γδ T cells on human ER+ and ER- breast cancer. | Nature Cancer

Extended Data Fig. 5: Impact of γδ T cells on human ER+ and ER- breast cancer.

From: IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages

Extended Data Fig. 5

a-c, Disease specific (DSS, a) and overall survival (OS, b, c) of ER− (a, c) and ER+ (b) METABRIC BC patients stratified by median-single-sample score of γδ T cell and IL17 signatures in high and low. Number of patients and P values (determined by Log-rank test) are reported. d-e, Representative images and quantification of CD8 (d) and CD68 (e) expression by immunohistochemistry in diagnostic HR+HER2− BC biopsies of indicated grade (grade 1: n = 16; grade 2: n = 55; grade 3: n = 13). Box-plots overlaid by individual data points show medians ± interquartile range; whiskers indicate minima and maxima. Number of patients are indicated. Only significant (P < 0.05) statistical differences (by Kruskal-Wallis with uncorrected Dunn’s test) are shown. Scale bars, 50 μm.

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