Extended Data Fig. 3: Single cell multiome analysis classified HSCs into four clusters. | Nature Aging

Extended Data Fig. 3: Single cell multiome analysis classified HSCs into four clusters.

From: Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow

Extended Data Fig. 3

(a) A heatmap of multiome analysis of young and aged mito-Dendra2 HSCs, showing the top differentially expressed genes in each cluster. The x-axis represents individual cells and clusters, and the y-axis represents differentially expressed genes. (b) Uniform manifold approximation and projection (UMAP) visualization of HSCs from young and aged mito-Dendra2 mice. scRNA-seq and scATAC-seq data were integrated with Weighted Nearest Neighbor (WNN) analysis. UMAP based on WNN analysis (top), scRNA-seq data only (middle), and scATAC-seq data only (bottom) were shown. In the right panels, young and aged mito-Dendra2 Low and High HSCs were depicted separately. The top leftmost panel is identical to Fig. 3b.

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