Fig. 4: TAAs have different predisposition to mitochondrial perturbations.
From: KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging
a, Representative flow cytometry plots showing the simultaneous analysis of MtG and MtDR in the different subsets of CD4+ T cells from 2- and 21-month-old mice: naive (blue), rTreg cells (yellow), aTreg cells (orange), kTreg cells (red), TEM (light green), cytotoxic (brown) and exhausted (dark green) (n = 6 mice per group). b, A comparison of the percentage of MtGloMtDRlo cells in each cluster of CD4+ T cells in young (2-month-old) and old (21-month-old) mice (n = 6 mice per group). c, A statistical comparison of the percentage of MtGloMtDRlo cells in the different clusters in young or old mice (n = 6 mice per group). Each dot represents an individual mouse. Data are presented as mean values ± s.e.m. Box-and-whisker plots show the median, the maximum, the minimum and the 25th and 75th percentiles. Statistical analysis was performed using two-tailed unpaired Student’s t-test (b: naive, rTreg, aTreg and TEM), Mann–Whitney U test (b: kTreg and exhausted) or Friedman test with post hoc Dunn’s correction (c). n.s., not significant; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Exact P values and additional statistical parameters can be found in the source data.
