Fig. 3: Lead variants and genes and genetic correlations of the HFRS. | Nature Aging

Fig. 3: Lead variants and genes and genetic correlations of the HFRS.

From: Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty

Fig. 3

a, Venn diagram showing the overlap of the lead variants associated with the full HFRS and the HFRS without dementia in FinnGen and those reported in the literature. Previous GWASs refers to genes identified in for the FI10, FP11 and mvAge13. b, Venn diagram showing the overlap of the lead variant genes associated with the full HFRS and the HFRS without dementia in FinnGen and those reported in the literature. c, Genetic correlations between HFRS in FinnGen and other frailty-related traits estimated using linkage disequilibrium score regression. All the correlations were statistically significant at P < 2.2 × 10−16.

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