Table 1 Characteristics of the study samples

From: Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty

Characteristic

FinnGen

UK Biobank

No. of individuals

519,200

407,463

Age at baseline assessment, mean (s.d.)

53.1 (17.9)

56.9 (8.0)

Age at end of follow-up/death, mean (s.d.)

60.8 (18.0)

70.9 (7.9)

Sex, n (%)

 Women

292,784 (56.4)

220,208 (54.1)

 Men

226,416 (43.6)

187,255 (45.9)

BMI (kg/m2), mean (s.d.)

27.35 (5.53)

27.41 (4.76)

 Missing, n (%)

142,454 (27.4)

1273 (0.3)

Smoking, n (%)

 Nonsmoker

156,355 (50.9)

221,770 (54.6)

 Former smoker

70,317 (22.9)

143,384 (35.3)

 Current smoker

80,736 (26.2)

41,109 (10.1)

 Missing

211,792

1,380

HFRS, median (IQR)

5.2 (1.6–10.4)

1.5 (0–5)

 Women, median (IQR)

5.3 (1.6–10.5)

1.5 (0–4.7)

 Men, median (IQR)

5.0 (1.5–10.3)

1.5 (0–5.4)

HFRS categories, n (%)

 Low risk (<5)

241,656 (48.4)

304,555 (74.7)

 Intermediate risk (5–15)

188,147 (37.8)

74,386 (18.2)

 High risk (>15)

65,925 (13.2)

28,702 (7.0)

HFRS > 5, n (%)

254,874 (51.0)

101,326 (24.9)

HFRS > 5 before age 65, n (%)

95,410 (18.4)

33,485 (8.2)

Died during follow-up, n (%)

62,764 (12.1)

36,795 (9.0)

Number of hospitalizations, median (IQR)

8 (4–17)

1 (0–3)

  1. FinnGen participant characteristics are presented for the sample with non-missing data on the HFRS (N = 519,200).
  2. IQR, interquartile range.