Fig. 2: FAB02 maintains monomeric structure under thermal and chemical stress conditions. | Communications Medicine

Fig. 2: FAB02 maintains monomeric structure under thermal and chemical stress conditions.

From: FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models

Fig. 2

Representative size exclusion-ultra performance liquid chromatography traces from 10 µL injections of 1.0 mg/ml FAB02 native or previously subjected to stressed conditions. Thermal stress was evaluated by freeze/thaw cycles (−80 °C to room temperature (RT)) (a) and to high temperature (50 °C) (b). Chemical stress consisted of forced oxidation with 0.5% hydrogen peroxide (c) and by exposure to 1% ammonium bicarbonate (d) at RT at the indicated time points.

Back to article page