Fig. 8: DYNE−101 low repeat monthly dosing reduces WT DMPK expression in the muscle of cynomolgus monkeys. | Communications Medicine

Fig. 8: DYNE−101 low repeat monthly dosing reduces WT DMPK expression in the muscle of cynomolgus monkeys.

From: FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models

Fig. 8

WT DMPK expression in muscle of male cynomolgus monkeys a 4 weeks after a single IV infusion with DYNE−101 (blue bars) or b or 4 weeks following the last of 2 monthly infusions (blue bars), relative to expression in the same muscle of monkeys infused with vehicle (gray bars), shown for each ASO-equivalent dose. Data are means + SD; data were analyzed by one-way ANOVA followed by uncorrected Fisher’s LSD test, statistically significant differences from vehicle are indicated with exact P values. Each circle represents an individual monkey.

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