Table 4 Comparison of different adenovirus vaccine vectors for stability by viral titre loss

From: A lyophilised formulation of chimpanzee adenovirus vector for long-term stability outside the deep-freeze cold chain

Compositions

Viral-titre loss at lyophilization

Storage duration & temperature

Viral-titer loss in storage

Overall viral-titre loss

Reference

( − log10)

(−log10)

 

ChAd155

0.12

5 years; 5 °C

0.21

0.33

This report

ChAdOx1-RVF

0.4

1 year; 4 °C

≈0

0.4

Berg et al. 13

ChAdOx2-RabGa

0.8

3 months; 4 °C

≈0.2

≈1.0

ChAdOx1-lucb,c

≈0.25

6 months; 4 °C

≈0

≈0.25

Zhang et al. 14

ChAdOx1-ncov19b

≈0.2

-

-

-

ChAdOx2-RabGa,b

≈0.5

-

-

-

hAd5-E10A (S1)d

0.25

6 months; 4 °C

0.08

0.33

Chen et al. 15

hAd5-E10A (L1)d

0.12

6 months; 4 °C

0.05

0.17

  1. aDifferent formulations of ChAdOx2-RabG.
  2. bViral-titre loss at the lyophilisation stage also included 1-month storage at 30 °C.
  3. cViral-titre loss was measured by loss of activity of luciferase encoded and expressed by the vaccine vector.
  4. dL1 and S1 were different formulations of hAd5-E10A.
  5. The almost-equal-to symbol (≈) reflects a value inferred from graphical representation.
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