Fig. 5: Transcriptome analysis of P0 vs. P4 tumors treated with anti-PD1 Ab. | Communications Medicine

Fig. 5: Transcriptome analysis of P0 vs. P4 tumors treated with anti-PD1 Ab.

From: Acquired resistance to immune checkpoint therapy is caused by glycoprotein non-metastatic melanoma protein B signal cascade

Fig. 5

a A total of 18,301 genes were analyzed between control- vs. PD1 Ab-treated tumors and expressed as Volcano Plots shown with statistical significance (Log10P from 2 or 3 data batches, y-axis) vs. Log2FC x-axis. Each dot (gene expression) shows values in PD1 Ab samples relative to control Ab. Blue, gray, and red dots show up-, non-significant, and down-regulation, respectively. b Heatmap analyses of top 40 differentially expressed genes (DEGs) in P0 or P4 tumors treated with PD1 vs. control Ab are shown.

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