Table 2 Prognostic value of patient and tumor characteristics for PFS and OS
Progression free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|
Characteristic | N | HR | 95% CI | p-value | HR | 95% CI | p-value |
Sex | 70 | ||||||
Female | Ref | — | Ref | — | |||
Male | 1.38 | 0.82, 2.33 | 0.23 | 1.25 | 0.69, 2.27 | 0.46 | |
Age | 70 | 0.99 | 0.97, 1.01 | 0.40 | 0.99 | 0.97, 1.02 | 0.55 |
ECOG PS | 70 | ||||||
0 | Ref | — | Ref | — | |||
1 | 0.94 | 0.56, 1.58 | 0.82 | 1.20 | 0.68, 2.10 | 0.53 | |
Primary tumor site | 70 | ||||||
GEJ | Ref | — | Ref | — | |||
Stomach | 1.61 | 0.99, 2.63 | 0.055 | 2.22 | 1.28, 3.83 | 0.004 | |
Tumor subtypea | 70 | ||||||
Diffuse | Ref | — | Ref | — | |||
Intestinal | 0.82 | 0.49, 1.37 | 0.46 | 0.67 | 0.38, 1.18 | 0.17 | |
Other | 0.56 | 0.21, 1.45 | 0.23 | 0.62 | 0.21, 1.81 | 0.38 | |
Resection of primary tumor | 70 | ||||||
No | Ref | — | Ref | — | |||
Yes | 0.97 | 0.57, 1.66 | 0.91 | 1.09 | 0.61, 1.93 | 0.78 | |
Liver metastasis | 70 | ||||||
No | Ref | — | Ref | — | |||
Yes | 1.90 | 1.14, 3.15 | 0.014 | 1.16 | 0.68, 1.99 | 0.59 | |
Lung metastasis | 70 | ||||||
No | Ref | — | Ref | — | |||
Yes | 0.96 | 0.52, 1.77 | 0.89 | 0.77 | 0.39;1.54 | 0.46 | |
Peritoneal carcinomatosis | 70 | ||||||
No | Ref | — | Ref | — | |||
Yes | 1.19 | 0.71;2.00 | 0.51 | 1.99 | 1.13; 3.50 | 0.017 | |
Lymph node metastasis | 70 | ||||||
No | Ref | — | Ref | — | |||
Yes | 0.91 | 0.56;1.48 | 0.71 | 0.92 | 0.54; 1.59 | 0.77 | |
Time to metastatic disease | 70 | ||||||
Metachronous | 0.76 | 0.45;1.27 | 0.29 | 0.86 | 0.5;1.48 | 0.62 | |
Synchronous | Ref | — | Ref | — | |||
LDH (times normal) | 64 | 1.86 | 1.17, 2.96 | 0.009 | 1.91 | 1.20, 3.03 | 0.006 |
ALP (times normal) | 69 | 1.32 | 1.04, 1.68 | 0.024 | 1.37 | 1.08, 1.74 | 0.009 |
NLR | 69 | 0.18 | 0.01, 2.58 | 0.20 | 0.14 | 0.01, 3.36 | 0.22 |
HER2 status | 70 | ||||||
Negative | Ref | — | Ref | — | |||
Positive | 0.48 | 0.26, 0.88 | 0.017 | 0.39 | 0.19, 0.81 | 0.011 | |
CPS PD-L1 | 48 | ||||||
CPS ≥ 5 | Ref | — | Ref | — | |||
CPS < 5 | 1.04 | 0.55;1.95 | 0.91 | 1.05 | 0.54; 2.03 | 0.89 | |
TPS PD-L1 | 48 | ||||||
TPS ≥ 1 | Ref | — | Ref | — | |||
TPS < 1 | 1.30 | 0.66; 2.59 | 0.45 | 1.32 | 0.64; 2.73 | 0.45 | |
ctDNA at diagnosis | 70 | ||||||
Negative | Ref | — | Ref | — | |||
Positive | 1.38 | 0.60, 3.21 | 0.45 | 1.40 | 0.51, 3.89 | 0.52 | |
As continuous variable | 1.05 | 0.99, 1.11 | 0.089 | 1.06 | 1.00, 1.12 | 0.046 | |
cfDNA at diagnosis | 70 | 1.04 | 1.01, 1.06 | 0.002 | 1.04 | 1.02, 1.07 | <0.001 |
ctDNA kinetics between C0 and C3 (decrease < 75%) | 54 | 2.09 | 1.19, 3.67 | 0.010 | 2.51 | 1.35, 4.68 | 0.004 |
