Fig. 5: hCiCMs improve cardiac function after MI. | Communications Medicine

Fig. 5: hCiCMs improve cardiac function after MI.

From: Reprogramming of human urine cells into cardiomyocytes via a small molecule cocktail in xeno-free conditions

Fig. 5

a Schematic drawing of the experimental procedure. Myocardial infarction (MI) was induced by LAD ligation. b Representative cardiac ultrasound images of baseline and 4 W in MI-NOD mice from vehicle control group and hCiCMs transplantation group. Mice were subjected to sham operation or MI by LAD ligation (sham = 4, vehicle = 7, hCiCMs = 8). c Evaluation of cardiac functions with echocardiography. Ejection fraction (EF), fractional shortening (FS), left ventricular volume at systole (LV vol, S), left ventricular volume at diastole (LV vol, d), and left ventricular mass(LV mass) were assessed in pre- and post-treatment mice. Statistical analysis was performed by two-tailed unpaired t test. Exact p values are provided in a file named Supplementary Data 5 (sham = 4, vehicle = 7, hCiCMs = 8). d Images of Masson trichrome staining of the heart sections (as presented in (c, d) (from the MI mice treated with hCiCMs or vehicle. Scale bar =1 mm. e Quantitative analysis of infarct size of (d). Statistical analysis was performed by two-tailed unpaired t test. Exact p values are provided in a file named Supplementary Data 5.

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