Fig. 1: Conditioning regimen platform. | Communications Medicine

Fig. 1: Conditioning regimen platform.

From: Haplo-stem cell transplant post liver transplantation to cure sickle cell disease with related liver dysfunction: a case series

Fig. 1

The regimen consisted of thymoglobulin 4.5 mg per kilogram of body weight day −9 to −7; thiotepa 10 mg per kilogram of body weight on day −7; cyclophosphamide 29 mg/kg total day −6 and day −5; fludarabine 30 mg/m2 from day −6 to day −2 or 150 mg/m2 total, and 200-cGy total-body irradiation on day −1. GVHD prophylaxis consisted of cyclophosphamide 50 mg per kilogram of body weight administered on days +3 and +4, mycophenolate mofetil 15 mg per kilogram of body weight commencing on day +5 through day +35, and sirolimus starting on day +5 through 1 year after BMT. All patients received unmanipulated, GCSF-mobilized bone marrow. BM bone marrow, BMT bone marrow transplantation, GCSF granulocyte colony-stimulating factor, GVHD graft-versus-host disease prophylaxis, MMF mycophenolate. mofetil; PO, given orally; PT post-transplantation cyclophosphamide, TBI total-body irradiation, TID three times a day.

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