Fig. 1: Cnga1-/- mice show a progressive loss of photoreceptor cells. | Communications Medicine

Fig. 1: Cnga1-/- mice show a progressive loss of photoreceptor cells.

From: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa

Fig. 1

A Representative OCT images of wild-type and Cnga1-/- mice. Asterisks mark the photoreceptor nuclei layer. Scale bars, 100 μm. B Age-related thinning of the photoreceptor nuclei layer of Cnga1-/- mice compared with wild-type mice, as measured by OCT images. Mean ± SD. n = 6 eyes for both group at each time point. C Representative confocal images of immunohistochemistry with CNGA1 (red) and cone arrestin (CAR, a cone marker, green) show morphologically affected but still-persisting cones after advanced thinning of the photoreceptor nuclei layer in Cnga1-/- mice. Scale bar, 10 μm.

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