Fig. 3: Cnga1-/- mice show a ‘supernormal’ phase of cone-mediated function followed by a subsequent decline with age. | Communications Medicine

Fig. 3: Cnga1-/- mice show a ‘supernormal’ phase of cone-mediated function followed by a subsequent decline with age.

From: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa

Fig. 3

A Representative photopic (light-adapted) ERG waveforms in response to a series of flashes. Stimulus intensities are indicated in the left panel. B Quantification of b-wave amplitudes of Cnga1-/- mice compared to wild-type mice at 1 month (left), 3 months (middle) and 6 months (right) of age. Mean ± SEM. C Changes in b-wave amplitudes with age at stimulus intensities of 1.0 log cd s m−2 (left) and 2.0 log cd s m−2 (right). Mean ± SEM. For the wild-type group, n = 10 eyes at each time point. For the Cnga1-/- group, n = 12 eyes at month 1 and 3; n = 10 eyes at month 2, 4, 5; n = 8 eyes at month 6.

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