Fig. 5: Long-term preservation of photoreceptors in Cnga1-/- mice following gene augmentation therapy. | Communications Medicine

Fig. 5: Long-term preservation of photoreceptors in Cnga1-/- mice following gene augmentation therapy.

From: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa

Fig. 5

A Representative OCT images from treated Cnga1-/- mice at 3 months (top), 6 months (middle), and 9 months (bottom) of age showing clear preservation of photoreceptor layer thickness within the treated area. Asterisks mark the photoreceptor nuclei layer. ONH, optic nerve head. Scale bars, 100 μm. B Quantification of the photoreceptor layer thickness in treated Cnga1-/- retinae compared with untreated Cnga1-/- and wild-type retinae, as measured by OCT images. Mean ± SEM. ***P < 0.001; two-way ANOVA with Tukey’s multiple comparisons. P value is <0.0001. n = 6 for each group at each time point. C Representative eye section from a 9-month-old treated Cnga1-/- mouse. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer. Scale bars, 200 μm in the middle panel and 50 μm in the magnified panels.

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