Fig. 6: Long-term rescue of retinal function in Cnga1-/- mice after gene augmentation therapy. | Communications Medicine

Fig. 6: Long-term rescue of retinal function in Cnga1-/- mice after gene augmentation therapy.

From: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa

Fig. 6

A Representative scotopic (dark-adapted) ERG waveforms in response to a series of flashes from wild-type (left), untreated Cnga1-/- (middle), and treated Cnga1-/- mice (right) at 9 months of age. B Quantification of a-wave amplitudes of untreated and treated Cnga1-/- mice at 9 months of age. Mean ± SEM. **P < 0.01; two-way ANOVA with Šídák’s multiple comparisons. P values are 0.008 at 0, 0.002 at 0.5, and 0.0034 at 1 light intensities. C Quantification of scotopic b-wave amplitudes of untreated and treated Cnga1-/- mice at 9 months of age. Mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001; two-way ANOVA with Šídák’s multiple comparisons. P values are 0.0208 at −1.5, 0.0067 at −1, 0.0017 at −0.5, 0.0003 at 0, and <0.0001 at higher light intensities. The numbers of eyes were as follows: treated Cnga1-/-, n = 10; untreated Cnga1-/-, n = 4. D Representative photopic (light-adapted) ERG waveforms in response to a series of flashes from wild-type (left), untreated Cnga1-/- (middle), and treated Cnga1-/- mice (right) at 9 months of age. E Quantification of photopic b-wave amplitudes of untreated and treated Cnga1-/- mice at 9 months of age. Mean ± SEM. ***P < 0.001; two-way ANOVA with Šídák’s multiple comparisons. P values are 0.0807 at −1, 0.0567 at 0, and <0.0001 at higher light intensities.

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