Fig. 7: Improvement of vision-guided behavior in 9-month-old Cnga1-/- mice after gene augmentation therapy. | Communications Medicine

Fig. 7: Improvement of vision-guided behavior in 9-month-old Cnga1-/- mice after gene augmentation therapy.

From: Gene augmentation therapy restores vision and preserves photoreceptors in a mouse model of CNGA1-retinitis pigmentosa

Fig. 7

A Representative swimming route on day 3. B Quantification of the success rate to locate the platform within 1 minute from day 1 to day 3. **P < 0.01, two-way ANOVA with Tukey’s multiple comparisons. Asterisks indicate a significant difference between treated and untreated Cnga1-/- mice at day 3. P value is 0.0026. C Quantification of the escape latency from day 1 to day 3. ***P < 0.001, two-way ANOVA with Tukey’s multiple comparisons. Asterisks indicate a significant difference between treated and untreated Cnga1-/- mice at day 3. P value is <0.0001. D Quantification of the total path length from day 1 to day 3. ***P < 0.001, two-way ANOVA with Tukey’s multiple comparisons. Asterisks indicate a significant difference between treated and untreated Cnga1-/- mice on day 3. P value is <0.0001. The numbers of mice were as follows: wild-type, n = 4; untreated Cnga1-/-, n = 4; treated Cnga1-/-, n = 5. Each mouse completed 8 trials per day.

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