Fig. 1: Principal component analysis of the 6926 SOMAmer aptamers and association with maternal characteristics.
From: Protein networks are influenced by maternal BMI and differentiate preterm birth types
a Study experimental study design. A line corresponds to a single patient, and each dot corresponds to the Gestational Age (GA) as to when the was sample collected. The GA of when the mothers delivered is indicated by the triangle b Heatmap shows the -log10(p-value) of the linear regression each of the Top 10 PCs against the following maternal covariates: Maternal Age (years), GA at blood draw (weeks), PTB status (mPTB or sPTB or Ctrl), sex of the fetus (male or female), whether mothers delivered before 35 weeks GA, and body mass index (BMI) (<30 or ≥30 kg/m2 c Violin plot relating PC6 against BMI (<30 or ≥30 kg/m2) (left) and PTB status (Control, sPTB, and mPTB) (right). The middle blank line represents the median, whereas the other lines represent the first and third quartiles. Significance was determined by a Kruskal–Wallis followed by the Benjamini–Hochberg procedure for multiple hypothesis correction. If statistically significant, a two-sided Mann–Whitney U test was performed (< 30 vs > = 30 BMI p-value = 0.0004; Control vs mPTB p-adj = 0.0103). *p <0.05, **p <0.01, ***p <0.001.
