Fig. 4: Gram-scale and late-stage derivatization. | Nature Synthesis

Fig. 4: Gram-scale and late-stage derivatization.

From: Difunctionalization of bicyclo[1.1.0]butanes enabled by merging C−C cleavage and ruthenium-catalysed remote C−H activation

Fig. 4

a, Gram-scale reaction gave the desired product 4 in high yield. b, Various downstream functionalization of products 4, 42 or 46. Cp*, 1,2,3,4,5-pentamethylcyclopentadienyl; DCE, 1,2-dichloroethane; LED, light emitting diode; MMA, methyl methacrylate; Piv, pivaloyl; PMP, p-methoxyphenyl; r.t., room temperature; THF, tetrahydrofuran.

Back to article page