Nanocrystals are increasingly used in high-tech applications and consumer products, but water-stable variants for life science and healthcare applications have production bottlenecks owing to complex syntheses. Now, water-stable nanocrystals are made in a single step by replacing ‘oily’ reagents with oxygen-rich alkoxy ligands and solvents, endowing the nanocrystals with broad solvent dispersibility.
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References
Murray, C. B., Norris, D. J. & Bawendi, M. G. Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites. J. Am. Chem. Soc. 115, 8706–8715 (1993). This paper reports an early synthesis of compound nanocrystals in high-temperature nonpolar aliphatic solvents, which led to homogeneous nanocrystals with diverse compositions and structures.
Chan, W. C. & Nie, S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016–2018 (1998). This paper reports a widely used ligand-exchange method to synthesize biologically friendly nanocrystals originally prepared in oil-based solvents.
Smith, A. M. & Nie, S. Nanocrystal synthesis in an amphibious bath: spontaneous generation of hydrophilic and hydrophobic surface coatings. Angew. Chem. Int. Ed. 47, 9916–9921 (2008). This paper reports the synthesis of nanocrystals in OEG-based solvents, using an amphiphilic ligand to facilitate dispersion in aqueous solvents after synthesis due to micellaren capsulation.
Turo, M. J. & Macdonald, J. E. Crystal-bound vs surface-bound thiols on nanocrystals. ACS Nano 8, 10205–10213 (2014). This paper reports the stability of Cu2S nanocrystals synthesized at high temperatures using alkanethiols that are bound as part of the crystal lattice whereas nanocrystals exchanged with thiols at lower temperatures are less stable owing to weaker modes of ligand binding.
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This is a summary of: Sarkar, S. et al. Nanocrystal synthesis with alkoxy reagents for dispersion in polar and non-polar solvents. Nat. Synth. https://doi.org/10.1038/s44160-025-00764-0 (2025).
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Water-stable nanocrystals in a single step. Nat. Synth 4, 785–786 (2025). https://doi.org/10.1038/s44160-025-00768-w
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DOI: https://doi.org/10.1038/s44160-025-00768-w