Fig. 6: Synthetic route towards heptamer G8 with the S,R,S,S,S,S configuration. | Nature Synthesis

Fig. 6: Synthetic route towards heptamer G8 with the S,R,S,S,S,S configuration.

From: Synthesis of chiral sequence-defined oligomers via sulfur–fluoride and sulfur–phenolate exchange reactions

Fig. 6

Reaction conditions: (i) G1 (1 equiv.), bisphenol A (5 equiv.), DBU (5 equiv.), LiBr (2 equiv.), THF, r.t., 30 min; (ii) G6 (1 equiv.), 1d (3 equiv.), LiBr (4 equiv.), DBU (1.5 equiv.), THF, r.t., 2 h; (iii) G7 (1 equiv.), G4 (1.1 equiv.), DBU (1.5 equiv.), LiBr (2 equiv.), THF, r.t., 2 h. THF, tetrahydrofuran; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; tol, p-tolyl.

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