Fig. 1: Approaches to improve the enantioselectivity of metal-catalysed chemical reactions.
From: Strain-dependent enantioselectivity in mechanochemically coupled catalytic hydrogenation
a, Changing ligand (X-shaped unit), metal (m), solvent, temperature or pressure (white box). Colour differences in the catalyst complex represent different ligand or metal environments. b, Coupling the catalyst complex (same X-shaped unit and m) to variable tension in a supporting polymer matrix (grey lines represent first network; orange lines represent second network polymer). R and S indicate the enantiomeric forms of the product.
