Table 2 Enantioselectivity of Rh(I)-catalysed hydrogenation of reaction (1) as a function of ligand restoring force in methanol at 25 °C under H2 (1 atm) for 24 h
From: Strain-dependent enantioselectivity in mechanochemically coupled catalytic hydrogenation
Entry | MFP | Yield (%) | R (%) | S (%) | e.r. | e.e. (%) | Estimated force (pN) |
|---|---|---|---|---|---|---|---|
1 | Z(2,2) | >99 | 51 | 49 | 1.04 | 2 | −65 |
2 | Z(2,3) | >99 | 64 | 36 | 1.78 | 28 | −6 |
3 | E(3,3) | >99 | 77 | 23 | 3.35 | 54 | 130 |
4 | E(2,3) | >99 | 92 | 8 | 11.50 | 84 | 228 |
