Extended Data Fig. 2: TEM images of platelets induced by apoptosis, autophagy or pyroptosis agonists and apoptosis in severe sepsis patients. | Nature Cardiovascular Research

Extended Data Fig. 2: TEM images of platelets induced by apoptosis, autophagy or pyroptosis agonists and apoptosis in severe sepsis patients.

From: Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

Extended Data Fig. 2

a, Platelets were induced to apoptosis (10 μM ABT-737 induces apoptosis), autophagy (10 μM FCCP induces autophagy) and pyroptosis (10 μg/ml LPS and 5 μM Nigericin induces pyroptosis). TEM imaging of different states in platelets. b, Representative lower and higher power TEM field demonstrating loss of platelet ultrastructure in severe sepsis (with or without septic shock) patients (n = 5), with reduced granules/organelles and increased vacuolation. Apoptosis, red arrowheads indicate shrinkage of cell membrane and apoptotic bodies in apoptosis of platelet. Scale bars: 1 μm and 500 nm. Severe sepsis, severe sepsis/septic shock; PLTs, platelets.

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