Extended Data Fig. 5: Temporal ACTN2 enhancer activation in mice.
From: A transcriptional enhancer regulates cardiac maturation
a. Analysis of ENCODE ChIP-Seq datasets for H3K27Ac and H3K4me1 from mouse hearts at different developmental stages showed increased ACTN2 enhancer activation in older mice supporting a role in the temporal regulation of ACTN2 gene expression. b. Analysis of P300 occupancy data from mouse hearts at different developmental stages, similarly, showed an increased in P300 peaks in postnatal hearts. c. Mef2a ChIP-Seq data showing binding of Mef2a in the ACTN2 enhancer region in adult mouse hearts.
