Extended Data Fig. 4: Risk of Study Outcomes According to Cardiovascular Risk Among High-Proportion Spliced-In Titin Truncating Variant Carriers. | Nature Cardiovascular Research

Extended Data Fig. 4: Risk of Study Outcomes According to Cardiovascular Risk Among High-Proportion Spliced-In Titin Truncating Variant Carriers.

From: Titin truncating variants, cardiovascular risk factors and the risk of atrial fibrillation and heart failure

Extended Data Fig. 4

This figure depicts the adjusted hazard ratio for study outcomes according to the cardiovascular risk profile among high-proportion spliced-in Titin truncating (hiPSI TTNtv) carriers. The cardiovascular risk was determined using the Pooled Cohort Equations and categorized into 3 groups [low (<5.0%), intermediate (5.0%-7.5%), and high (>7.5%)]. The low cardiovascular risk group was taken as the reference group. Data are presented as hazard ratio and 95% confidence interval. HR (95% CI) in the figure indicates the hazard ratio and 95% confidence interval. Panel A depicts the primary outcome. Panels B, C, and D depict the secondary outcomes of atrial fibrillation, heart failure, and all-cause mortality, respectively.

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