Extended Data Fig. 1: Mouse strains in this study and the design of AAA experiments. | Nature Cardiovascular Research

Extended Data Fig. 1: Mouse strains in this study and the design of AAA experiments.

From: The TRPM7 chanzyme in smooth muscle cells drives abdominal aortic aneurysm in mice

Extended Data Fig. 1

(a) Inducible knockout (iKO) of SMC Trpm7 with tamoxifen (Tam.) treatment. Please note the serendipitous insertion of the Myh11 promoter-driven Cre transgene into the Y chromosome. (b) The protocol for saline or PPE perfusion in SMC-selective Trpm7 null mice (Trpm7sm-iKO). Detailed information on data collection can be found in the Methods section. (c) Inducible knockout of Trpm7 with tamoxifen treatment on Apoe-/- background. (d) The protocol for saline or Ang II infusion in Apoe-/-; Trpm7sm-iKO mice. Please see the Methods section for information on data acquisition.

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