Extended Data Fig. 6: Canrenone treatment improved porcine donor heart function after 4 h of preservation.
From: Mineralocorticoid receptor phase separation modulates cardiac preservation
Ex-vivo assessment of pig hearts preserved with HTK ± Canrenone (Canr) treatment for 10 h. Hemodynamic and coronary measurements recorded in working mode after 1 h of perfusion include a, contractility (max dP/dt), b, relaxation (min dP/dt), c, cardiac output (ml/min/g) and d, coronary blood flow, e, Cardiac troponin I (cTnI) were quantified in ex-vivo perfusate for porcine heart (n = 8 per group). f. Western blot of BAX, Cleaved CASPASE 3 and BCL2 in ex-vivo perfused human heart. g. Quantification of western blots (n = 4). Data are presented as means ± SD. *P < 0.05 and **P < 0.01 by two-sided Mann-Whitney test.
