Extended Data Fig. 10: Schematic summarization of the findings. | Nature Cardiovascular Research

Extended Data Fig. 10: Schematic summarization of the findings.

From: Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases

Extended Data Fig. 10

(a) Molecular and cellular mechanisms by which tetraspanin CD82 regulates AC and its non-vesicular transfer and then GEF/GAP-Rho small GTPases signaling, to alter the inflammatory status of cells and tissues. (b) New therapeutic strategies against inflammation arisen from this study. Red thunder signs denote functional blocking, and green asterisk signs indicate functional strengthening.

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