Fig. 2: Differentially expressed gene (DEG) analysis comparing each group. | npj Mental Health Research

Fig. 2: Differentially expressed gene (DEG) analysis comparing each group.

From: Intron retention: a novel method for evaluating the response to ketamine in patients with treatment-resistant depression

Fig. 2

A DEG analysis between nonresponders and CONs (baseline). (i) Volcano plots of RNA expression comparisons are shown. The vertical axis shows −log10 p values, and the horizontal axis shows log2 fold-change. Genes with significant changes in expression are shown in red (upregulated) and blue (downregulated) (threshold: p < 0.05 and fold change >1.2). Symbols indicate the top 10 genes with the lowest p values among the up- and downregulated genes. (ii, iii) GO enrichment analysis of upregulated (ii) and downregulated (iii) genes in nonresponders. The horizontal axis indicates −log10 p values. The vertical axis indicates enriched GO terms, and the number of genes corresponding to each term is indicated in parentheses. GO terms related to innate immunity are indicated in bold. B (i, ii, iii) DEG analysis between responders and CONs (baseline). C (i, ii, iii) DEG analysis between nonresponders and responders (baseline).

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