Fig. 3: Changes in intron retention ratios and differences in ketamine responsiveness between patients and healthy controls. | npj Mental Health Research

Fig. 3: Changes in intron retention ratios and differences in ketamine responsiveness between patients and healthy controls.

From: Intron retention: a novel method for evaluating the response to ketamine in patients with treatment-resistant depression

Fig. 3

A Intron retention analysis between nonresponders and CONs (baseline). (i) Scatter plots of IR ratio comparisons are shown. The vertical axis shows the −log10 p values, and the horizontal axis shows the difference in the IR ratio (∆IR). Genes with significant changes are shown in red (IncIR genes) and blue (DecIR genes) (threshold: p < 0.05 and absolute ∆IR > 0.05). Symbols indicate the top 10 genes with the lowest p values among the respective IncIR and DecIR genes. (ii) GO and KEGG enrichment analyses were performed by merging the IncIR and DecIR genes. The horizontal axis indicates −log10 p values. The deep blue bars indicate GO terms, and the orange bars indicate KEGG pathway names. The vertical axis indicates enriched GO/KEGG terms, and the number of genes corresponding to each term is indicated in parentheses. Bold indicates GO/KEGG terms related to innate immunity. B (i, ii) Intron retention analysis between responders and CONs (baseline). C Venn diagram showing inflammation- or immunity-related genes among IncIR/DecIR genes in the nonresponder group. (i) Comparison with gene sets containing the term “GO:0006954 inflammatory response” (508 genes). (ii) Comparison with gene sets containing the term “GO:0045087 innate immune response” (698 genes). (iii) Comparison with gene sets containing the term “GO:0002250 adaptive immune response” (764 genes). D (i, ii, iii) Venn diagram showing inflammation- or immunity-related genes among the IncIR/DecIR genes in the responder group.

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