The extracellular matrix remains under-recognized as a sex-dependent entity. Designing culture environments that account for sex as a biological variable requires considering not only cellular sex, but also the usage of sex-specific scaffolds to create a holistically sex-accurate platform.
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The authors acknowledge funding from the National Institutes of Health (R01 HL172046 to K.S.M.).
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Borelli, A.N., Masters, K.S. Developing sex-accurate cell culture environments. Nat Rev Bioeng 3, 2–3 (2025). https://doi.org/10.1038/s44222-024-00265-3
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DOI: https://doi.org/10.1038/s44222-024-00265-3
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