Volume 3 Issue 9, September 2025

Lipid nanoparticles deliver mRNA without considering the amount and type of ‘supporting molecules’ (SUMs) available in the cell to process them. Here we discuss how co-delivering SUMs with mRNA payloads can provide a simple yet effective strategy for amplifying their performance toward the creation of safer and more-effective therapeutics.

To ensure comprehensive understanding of blood group antigens — including minor antigens — blood transfusions require extended erythrocyte phenotyping or genotyping. However, such advanced testing is frequently unavailable in resource-limited settings. Implementing point-of-care testing on extended blood group antigens can enhance patient care in transfusion medicine by improving the accessibility, safety and efficiency of blood transfusions.

Insect pest control, which is essential for food and crop production, typically relies on chemical insecticides. At Yngvi Bio, we repurpose bacterial contractile injection systems as biodegradable insecticides, offering ecological safety, target specificity and a scalable path to market.

The CL1 is a scalable device for interacting with in vitro neural cell cultures via electrical activity in a closed-loop real-time environment coupled with an integrated life-support perfusion circuit. Here we explore the key component that constitutes the CL1 along with the various opportunities this platform technology can address.

An article in Nature Biomedical Engineering demonstrates a needle-free floss-based vaccination platform that can be self-administered and triggers systemic and mucosal immune responses.

Structural anisotropy is crucial for the function of various human tissues such as myocardial and locomotion muscles and cornea. In this Review, the authors summarize the development of structural anisotropy in native tissues and discuss in vitro reductionist approaches to understand and direct anisotropy for tissue regeneration applications.

Polyethylene glycol (PEG) is used in many nanomedicines but might cause the production of anti-PEG antibodies. This Review critically assesses mechanisms and effects of PEG immunogenicity and explores strategies to address PEG immunogenicity in the context of nanomedicine.

New organs can be engineered based on decellularized human and animal tissues to address the global shortage of donor organs. This Review discusses design principles for the engineering of new organs using decellularized animal-derived tissues, including decellularization, functionalization and characterization protocols.

Beyond vaccines, RNA–lipid nanoparticle (LNP) nanomedicines have originally focused on cancer applications. This Review discusses how these therapeutics can also benefit acute critical illnesses (ACIs) owing to the short-term expression of mRNA while mitigating the adjuvant effect of LNPs, which, unlike in vaccines and cancer, can be a liability for ACIs.

Synthesis-planning algorithms equipped with accurate knowledge of reaction rules can nowadays rival designs of expert organic chemists. This Review discusses how computer-assisted synthesis is used to help design routes that are not only chemically correct but also green, sustainable or circular.