Table 3 The relationship between KIT or PDGFRA mutation status and preceding TKIs.
Sample No. | Preceding TKIs | Mutational statusa | KIT | PDGFRA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Exon 9 | Exon 10 | Exon 11 | Exon 13 | Exon 17 | Exon 18 | Exon 20 | Exon 18 | |||
1 | IM | Resistant | A502_Y503dup | – | – | – | N822K N822Y | – | – | – |
2 | SU | No-resistant | A502_Y503dup | – | – | – | – | – | – | – |
3 | SU | Resistant | – | – | – | – | D820Y | – | – | – |
4 | REG | Resistant | – | – | W557G | – | – | – | – | – |
5 | REG | Resistant | – | – | – | V654A | – | – | – | – |
6 | SU | No-resistant | – | – | – | V654A | – | – | – | – |
7 | SU | Resistant | – | – | V569_L576del | N822K | – | – | – | |
8 | SU | Resistant | – | – | – | S628G K642E | N822K | – | – | – |
9 | IM | Resistant | – | – | – | – | – | A829P | – | – |
10 | REG | Resistant | – | – | – | V654A | N822K | – | – | – |
11 | IM | No-resistant | – | – | W557_E561del | – | – | – | – | – |
12 | SU | Resistant | – | F529S | E554_K558del | V654A | – | – | – | – |
13 | IM | Resistant | A502_Y503dup | – | – | – | – | – | – | – |
14 | REG | Resistant | – | – | – | – | – | E925K | D842_S847 > EF | |
15 | IM | Resistant | A502_Y503dup | – | – | D820E | – | – | – | |
16 | IM | No-resistant | – | – | D579del | – | – | – | – | – |
17-1 | REG | Resistant | – | – | – | – | – | – | – | D842_S847 > EF |
17-2 | IM | Resistant | – | – | – | – | – | – | D901N E925K | D842_S847 > EF |
