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Gene delivery

Fine-tuning extracellular fluid viscosity enhances gene delivery

Nature Chemical Engineering volume 1, pages 559–560 (2024)Cite this article

Successful gene delivery is predicated on the effective cellular uptake of encapsulated nucleic acid cargo. Now, a study identifies extracellular fluid viscosity as a key factor that governs gene delivery via non-viral and viral vectors across a range of cell types.

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Fig. 1: Optimizing extracellular fluid viscosity enhances gene delivery.

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Authors and Affiliations

  1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

    Ajay S. Thatte, Dongyoon Kim & Michael J. Mitchell

  2. Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Michael J. Mitchell

Authors
  1. Ajay S. Thatte
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  2. Dongyoon Kim
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  3. Michael J. Mitchell
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Correspondence to Michael J. Mitchell.

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The authors declare no competing interests.

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Thatte, A.S., Kim, D. & Mitchell, M.J. Fine-tuning extracellular fluid viscosity enhances gene delivery. Nat Chem Eng 1, 559–560 (2024). https://doi.org/10.1038/s44286-024-00118-1

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