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Volume 2 Issue 9, September 2025

A focus on separations

Separation processes are experiencing rapid advancement, driven both by environmental challenges and scientific breakthroughs. This Focus issue presents primary research, alongside opinion, review and commentary pieces, that highlight how innovations across scales are shaping the future of chemical separations science and technology.

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Image: Yousef Mansour / 500px/500px / getty. Cover design: Laoise Mac Gabhann.

Editorial

  • Chemical separations are undergoing a period of rapid advancement, driven by both environmental pressures and scientific breakthroughs. From electrochemical alternatives to advanced materials and intensified processes, this Focus issue highlights how innovations across scales are shaping the future of chemical separations science and technology.

    Editorial

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Comment & Opinion

  • This Comment explores why continuous crystallization, despite its success in other industries, remains underutilized in pharmaceutical manufacturing. Among other challenges, we highlight two core issues: the lack of off-the-shelf small-scale equipment with integrated monitoring tools, and the absence of compatible continuous downstream units for filtration and drying, both of which limit practical implementation.

    • Giovanni Aprile
    • Cedric Devos
    • Allan S. Myerson
    Comment
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Features

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Research Highlights

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News & Views

  • Chemical recycling of mixed polyester waste presents a monumental challenge for achieving a circular plastics economy due to material incompatibility and contamination. Now, a catalytic methanolysis process demonstrates a scalable, efficient and selective method for recycling mixed polyester waste.

    • Kevin M. Van Geem
    News & Views
  • Membranes with thin polymer layers (<100 nm), typically made via interfacial polymerization with large amounts of organic solvents, are essential for desalination and chemical separations. While membrane chemistry has diversified, fabrication methods have seen only incremental change. Now, a fully aqueous electrochemical synthesis brings innovation to membrane separations.

    • Suzana Nunes
    News & Views
  • Advancing the production of covalent organic frameworks toward faster and more sustainable routes is crucial to realizing their potential in large-scale applications. Now, a variety of covalent organic framework platelets with high crystallinity can be produced rapidly using a pressure-assisted hot-pressing strategy.

    • Sui Zhang
    News & Views
  • An engineered confinement device reveals how the microtubule cytoskeleton senses and adapts to its environment by harnessing the interplay between catastrophe instability and branching nucleation.

    • Ryota Sakamoto
    • Yusuke T. Maeda
    News & Views
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Reviews

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Research

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By the Numbers

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