Fig. 8: Microglial activation in JUAV-infected neonatal mice. | npj Viruses

Fig. 8: Microglial activation in JUAV-infected neonatal mice.

From: Juruaça virus taxonomy, tolerance and resistance to infection, and inflammatory response modulation in murine model

Fig. 8

Photomicrographs of IBA-immunostained brain sections from JUAV-infected neonatal mice (n = 9) at 12 days post-infection (dpi). A Low-magnification image showing microglia in the olfactory bulb. C Increased microglial density near the lateral ventricle. E Increased microglial density in the cerebellum. G Increased microglial density at the borders of adjacent cortical and mesencephalic regions. B, D, F, and H High-magnification views of the rectangular regions indicated in the low-power images, demonstrating morphological changes in microglia at various stages of reactivity. White arrows indicate microglia with thinner and thicker processes, while black arrows and arrowheads indicate round macrophage-like microglia and meningeal microglia, respectively. Control mouse sections (not shown) exhibited non-activated microglia. Scale bars: A, C, E, and G = 550 µm; B, D, F, and H = 100 µm; I = 1 mm. Microglial activation patterns were confirmed in two independent experiments.

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