Table 1 Virus binding and motility factors

	Morphology	Dimensions	Envelope proteins^a				Virus	Binding parameters^b									Kinetic activity parameters^c
	Morphology	Dimensions	Type	Height (nm)	Quatern. Struct.	Number^g		K_D (uM)					k_on (M^-1s^-1)		k_off (s^-1)		k_cat (s^-1)	K_m (uM)
								3SLN	9-O-3SLN	6SLN	9-O-6SLN	9-O-8Sia	3SLN	6SLN	3SLN	6SLN
CoV	spherical	80-120nm¹⁰³	S	17-20²⁰	trimer		HKU1¹⁰⁴		75.7		101	5.8					No enzymatic activity
			S	17-20²⁰	trimer		OC43²⁰		49.7					14000		1
			HE	5-7⁴⁸	dimer		HKU1¹⁰⁵											280^d
			HE	5-7⁴⁸	dimer		OC43¹⁰⁵											1200^d
Paramyxo	spherical	100-540nm^70,89	HN	16	tetramer/dimer		SeV¹⁰⁶										16.5	929
							hPIV1¹⁰⁶	79					6200		0.5		5.58	176-297
							hPIV2¹⁰⁷	28					12000		0.34		49	440
							hPIV3¹⁰⁶	4300					51		0.22		0.8-16	1.2-21x10³
							NDV¹⁰⁶										4.75	50.9
IAV	spherical or cylindrical	100 to 80x150¹⁰⁸	HA	14	trimer	209-301⁹⁴	H1N1										No enzymatic activity
							H5N1⁷⁷	2050		30000			274		0.67
							H3N2⁷⁷	3700-50400		2100-30600			19.6-258	28.8-382	0.76-1.34	0.63-1.16
	filamentous	85 x >10000nm^69,109	NA	13	tetramer	38-50⁹⁴	H1N1^107,110											153^e,7.5-31.5
							H5N1¹¹¹											78.9-110.5
							H3N2^112,113											4.1^f, 24-138
ICV	spherical	88-98nm^114,115	HEF	15¹¹⁵	trimer		ICV
ICV	filamentous	diverse^114,115	HEF	15¹¹⁵	trimer		ICV

^aProtein size is presumably the same for different morphologies.
^bBinding parameters for monovalent interactions.
^cKinetic parameters determined in soluble substrate cleavage assays using 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid (MUNANA) except when indicated otherwise.
^dDetermined by pNPA instead of MUNANA.
^eDetermined by STD-NMR instead of MUNANA.
^fDetermined by 5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid instead of MUNANA.
^gIndicates trimer/tetramer number per virion.

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