Fig. 3: Systemic effects of altered circadian regulation in MASH.
From: Potential bidirectional communication between the liver and the central circadian clock in MASLD
Disrupted circadian outputs from the diseased liver can affect metabolic and immune rhythms in other tissues. In MASH patients or animal models of fatty liver disease repercussions on rhythmic functions outside the liver have been shown for the SCN (sleep–wake cycle regulation), the arcuate nucleus (appetite regulation), metabolic tissues such as muscle (lipid and carbohydrate metabolism), and inflammatory processes in the lung and circulating immune cells.
