Fig. 2: Totum-448 does not have significant impact on intestine length and fecal microbiome composition. | npj Gut and Liver

Fig. 2: Totum-448 does not have significant impact on intestine length and fecal microbiome composition.

From: The polyphenol-rich plant extract Totum-448 decreases hepatic steatosis and inflammation in diet-induced MASLD mice

Fig. 2

LFD- and HFD/S-fed mice were treated as described in Fig. 1. The intestine and colon lengths and the cecum weight were measured post-sacrifice (a–c). Fecal microbiome alpha and beta diversity: species richness and evenness were assessed at phylum (d) and genus (g) level by Shannon index. Principal coordinate analysis of microbial composition using Bray-Curtis (e, h) and Jaccard (i) distances at phylum (e) and genus (h, i) levels. Average relative microbiome composition of fecal samples at phylum (f) and genus (j) levels. For visual clarity, only the most abundant 5 phyla and 20 genera are presented individually, the rest being summed up into “Others”. Results are expressed as mean ± SEM. n = 10–12 mice per group from 2 independent experiments (for a–c). n = 4–6 mice per group from 1 experiment (d–j).

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