Fig. 2: Nur77 structural domains and NR4A conservation. | npj Gut and Liver

Fig. 2: Nur77 structural domains and NR4A conservation.

From: Mechanisms of orphan nuclear receptor Nur77 in liver health, disease, and therapeutic potential: narrative review

Fig. 2

The schematic shows AF-1, DBD, hinge, and LBD contains AF-2. Brackets indicate sequence similarity among NR4A family (Nur77/NR4A1, Nurr1/NR4A2, NOR-1/NR4A3): AF-1 26–28%, DBD 94–95%, LBD (incl. AF-2) 58–65%120. The DBD has two C4 zinc-finger modules for DNA binding, and the LBD has the canonical 12-helix nuclear-receptor fold121. NR4A LBD: occluded pocket; atypical AF-228.

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