Table 2 Spirometry and CTFI Variables

From: CT-derived functional imaging biomarkers combined with FEV1 for predicting 10-year all-cause mortality in COPDGene cohort

 

All patients

GOLD 1

GOLD 2

GOLD 3

GOLD 4

Raw

P-value

Adjusted P-value*

(N = 3550)

(N = 614)

(N = 1533)

(N = 931)

(N = 472)

FEV1 (L)

1.56(1.05, 2.14)

2.62(2.13, 3.12)

1.81 (1.50, 2.21)

1.10 (0.93, 1.34)

0.64 (0.51, 0.79)

<0.001

<0.001

FEV1/FVC

0.55 (0.42, 0.64)

0.66 (0.63, 0.68)

0.60 (0.53, 0.65)

0.43 (0.37, 0.49)

0.30 (0.26, 0.36)

<0.001

<0.001

FVC

2.98 (2.34, 3.72)

4.08 (3.33, 4.79)

3.13 (2.57, 3.79)

2.62 (2.11, 3.21)

2.12 (1.62, 2.61)

<0.001

<0.001

CT vendor (%)

     

0.026

 

GE

37.2

39.3

38.2

35

35.8

Philips

5.4

3.6

4.8

6.6

7.6

Siemens

57.4

57.2

57

58.4

56.6

CT-V (L)

Global

2.00 (1.46, 2.66)

2.73 (1.99, 3.46)

2.13 (1.65, 2.71)

1.76 (1.32, 2.31)

1.52 (1.11, 1.86)

<0.001

<0.001

RUL

0.40 (0.28, 0.55)

0.49 (0.35, 0.65)

0.49 (0.35, 0.65)

0.37 (0.26, 0.50)

0.30 (0.21, 0.39)

<0.001

<0.001

RLL

0.51 (0.35, 0.70)

0.72 (0.54, 0.94)

0.54 (0.39, 0.72)

0.43 (0.29, 0.58)

0.36 (0.24, 0.48)

<0.001

<0.001

RML

0.12 (0.07, 0.18)

0.17 (0.12, 0.24)

0.13 (0.08, 0.19)

0.10 (0.06, 0.15)

0.08 (0.05, 0.12)

<0.001

<0.001

LUL

0.46 (0.33, 0.63)

0.59 (0.43, 0.78)

0.49 (0.36, 0.66)

0.42 (0.31, 0.56)

0.34 (0.24, 0.46)

<0.001

<0.001

LLL

0.48 (0.32, 0.67)

0.69 (0.49, 0.90)

0.51 (0.36, 0.69)

0.42 (0.28, 0.57)

0.34 (0.23, 0.49)

<0.001

<0.001

PBM

Global

68.2(39.5,104.9)

95.6(61.11,130.73)

73.8(45.90,110.54)

57.5(32.78,90.10)

46.9(28.70,69.54)

<0.001

<0.001

RUL

12.1(5.77,20.27)

15.3 (6.42, 24.29)

13.4 (6.41, 21.17)

11.1(5.28, 19.37)

8.92 (4.89, 14.95)

<0.001

<0.001

RLL

20.1(11.07,31.23)

30.4(19.59, 41.15)

22.8(13.46, 32.62)

15.9(8.74, 24.73)

13.1 (6.70, 19.70)

<0.001

0.001

RML

3.51 (1.56, 6.40)

3.8 (1.93, 7.16)

3.58 (1.57, 6.42)

3.45 (1.51, 6.27)

2.95 (1.20, 5.54)

<0.001

<0.001

LUL

13.9(6.71, 22.92)

16.3(7.62, 26.18)

15.0 (7.51, 24.49)

13.1(6.06, 21.34)

10.6(5.48, 17.15)

<0.001

<0.001

LLL

9.2(5.00, 10.60)

10.1(7.40, 11.00)

9.7 (5.70, 10.70)

8.0 (4.80, 10.20)

5.1 (2.70, 8.50)

<0.001

<0.001

  1. Numbers represent median (IQR) for FEV1, FEV1/FVC, FVC and CTV in L, PBM is in gm/L.
  2. RUL right upper lobe, RML right middle lobe, RLL right lower lobe, LUL left upper lobe, LLL left lower lobe.
  3. *P-values were adjusted using the Bonferroni method to account for multiple comparisons. Adjustments were performed separately for the Spirometry, CT-V, and PBM variable groups.
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