Table 1 Cox regressions showing associations between risk factors and incident Alzheimer’s disease

From: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340)

 

Hazard ratios

Lower 95% CI

Upper 95% CI

P value

N

Overall

 Verbal-numerical reasoning score

0.73

0.68

0.79

<0.001

81,228

 Log reaction time

1.17

1.13

1.20

<0.001

245,758

 Log visual memory errors

1.06

1.03

1.10

<0.001

247,368

In non-APOE e4 carriers

 Verbal-numerical reasoning score

0.64

0.56

0.72

<0.001

59,660

 Log reaction time

1.24

1.17

1.30

<0.001

180,060

In APOE e4 carriers

 Verbal-numerical reasoning score

0.79

0.72

0.87

<0.001

21,568

 Log reaction time

1.13

1.08

1.18

<0.001

65,698

  1. Associations are Cox regressions adjusted for age at time of assessment, sex, Townsend deprivation index, 10 genetic principal components, diagnosis of historic coronary heart disease, hypertension, diabetes, ever-smoking, college/university degree and genotypic array.
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