Figure 1

H & E stained liver sections from control and PFOA-exposed mice.

Liver sections were viewed under a light microscope. (a) Control mice fed a regular diet (RD); (b) RD-fed mice treated with 5 mg/kg/day PFOA; (c) RD-fed mice treated with 10 mg/kg/day PFOA; (d) RD-fed mice treated with 20 mg/kg/day PFOA; (e) Control mice fed a high-fat diet (HFD); (f) HFD-fed mice treated with 5 mg/kg/day PFOA; (g) HFD-fed mice treated with 10 mg/kg/day PFOA; (h) HFD-fed mice treated with 20 mg/kg/day PFOA. Hydropic degeneration with visible vacuoles in hepatocytes was observed in c and g; ballooning degeneration occurred in d and h. Scale bar in panel a, 200 μM.