Table 1 Organ Indexes and Serum lipid levels after a 14-Day Exposure to PFOA

From: Specific Accumulation of Lipid Droplets in Hepatocyte Nuclei of PFOA-exposed BALB/c Mice

Diet

Regular Diet

High-Fat Diet

Dose of PFOA (mg/kg/day)

0

5

10

20

0

5

10

20

Group

A

B

C

D

E

F

G

H

Na

15

15

14

13

15

14

13

11

Final Body Weight (g)

26.55 ± 0.45

23.21 ± 0.57**

17.79 ± 0.38**

14.44 ± 0.47**

27.91 ± 0.92

25.30 ± 0.86*

19.11 ± 0.62**

16.09 ± 0.67**

Liver Indexb

5.17 ± 0.14

12.01 ± 0.26**

13.75 ± 0.47**

13.83 ± 0.50**

6.41 ± 0.25

14.06 ± 0.42**

16.48 ± 0.57**

16.34 ± 0.56**

Fat Indexb

2.15 ± 0.24

1.41 ± 0.16*

0.14 ± 0.07**

0.13 ± 0.06**

2.15 ± 0.24

1.16 ± 0.16**

0.33 ± 0.16**

0.23 ± 0.06**

Albumin (g/L)

36.82 ± 0.93

36.48 ± 0.12

38.17 ± 0.66

38.15 ± 1.40

37.47 ± 0.98

36.05 ± 1.73

37.33 ± 0.96

37.87 ± 0.76

TG (mmol/L)

1.11 ± 0.26

0.74 ± 0.19

0.43 ± 0.12*

0.17 ± 0.04**

0.63 ± 0.16

0.38 ± 0.09

0.34 ± 0.06

0.62 ± 0.13

CHOL (mmol/L)

3.39 ± 0.22

3.22 ± 0.21

3.03 ± 0.27

2.16 ± 0.24**

5.21 ± 0.51

5.00 ± 0.69

4.41 ± 0.36

5.36 ± 0.44

HDL-ch (mmol/L)

1.85 ± 0.08

1.65 ± 0.07

1.68 ± 0.12

1.29 ± 0.13**

2.52 ± 0.20

2.57 ± 0.40

2.23 ± 0.22

2.97 ± 0.19

LDL-ch (mmol/L)

0.15 ± 0.02

0.18 ± 0.02

0.17 ± 0.01

0.10 ± 0.01*

0.40 ± 0.05

0.36 ± 0.10

0.41 ± 0.07

0.21 ± 0.04*

Glucose (mmol/L)

6.15 ± 0.29

5.80 ± 0.57

5.13 ± 0.64

3.02 ± 0.51**

7.70 ± 0.54

4.35 ± 0.65**

7.35 ± 0.56

6.12 ± 0.41*

Glycogen (mg/g liver)

6.67 ± 0.73

5.17 ± 0.74

1.33 ± 0.11**

1.50 ± 0.05**

3.33 ± 0.18

3.45 ± 1.05

1.57 ± 0.06**

1.17 ± 0.27**

  1. aNumber of exposed mice. Some animals died during the exposure: one for G and H on day 10; two for D, one for G and three for H on day 11; one for F and G on day 12.
  2. bLiver index and fat index were calculated as [organ weight (g)/body weight (g)] × 100.
  3. *P < 0.05, **P < 0.01 versus their respective controls or between the two indicated groups, using one-way ANOVA.
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