Figure 1 | Scientific Reports

Figure 1

From: Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC

Figure 1

Inhibition of ELIC by general anesthetics.

(a) Representative ELIC current traces elicited by propylamine (PPA) at EC20 in the absence and presence of the general anesthetics isoflurane (ISF, 50 μM), sevoflurane (SVF, 60 μM), halothane (HAL, 82 μM), propofol (PFL, 30 μM), etomidate (ETM, 30 μM), or thiopental (THP, 100 μM). The scale bars are 0.2 μA (vertical) and 30s (horizontal). The data were normalized to the current at EC20 in the absence of anesthetics and fit to the Hill equation (solid lines, n ≥ 6) for the volatile (b) and intravenous (c) general anesthetics. The best-fit parameters for both (b,c) are provided in Supplementary Table 1. The data are reported as the mean ± SEM and error bars less than the symbol size are not visible.

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