Figure 6: Exposure to environmental isolates of Streptomyces spp. resulted in dopaminergic neurodegeneration in C. elegans.
From: The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp.
(A–C). Representative images of C. elegans (strain BY200) expressing GFP specifically in the six anterior dopaminergic (DA) neurons. In all images, arrows show intact dopaminergic neuron cell bodies. Arrowheads indicate areas where dopaminergic neurons have degenerated. (A) An example of normal, intact, DA neurons that have not degenerated following 12 days exposure to negative control, E. coli. (B,C). C. elegans where all six DA neurons have degenerated following 12 days exposure to the S. venezuelae positive control (B) or a compound-producing Streptomyces sp. isolate (C). (D) Exposure to environmental isolates of Streptomyces spp. can cause significant neurodegeneration in populations of C. elegans.
