Table 1 Characteristics of subjects.
From: Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD
Discovery group | Validation group | All subjects | |
|---|---|---|---|
(n = 252) | (n = 126) | (n = 378) | |
Age (years) | 44 (31–55) | 40 (28–53) | 43 (30–54) |
Gender (women/men) | 152/100 | 81/45 | 233/145 |
fS-pIGFBP-1 (μg/l) | 56 (33–109) | 67 (28–96) | 58 (32–106) |
PNPLA3 genotype (I148II/IM/MM) | 56%/35%/10% | 49%/42%/9% | 52%/36%/9% |
Liver fat% | 5.0 (1.0–12.0) | 4.7 (1.0–12.0) | 4.9 (1.0–12.4) |
NAFLD (no/yes) | 134/118 | 70/56 | 204/174 |
S-ALT (U/l) | 33 (21–51) | 30 (20–53) | 32 (21–51) |
S-AST (U/l) | 28 (23–40) | 29 (22–40) | 28 (23–40) |
Weight (kg) | 92.3 (79.9–118.2) | 97.0 (81.5–114.7) | 94.2 (80.9–115.2) |
BMI (kg/m2) | 32.6 (27.7–39.5) | 33.0 (28.9–40.7) | 32.7 (28.1–39.7) |
Waist circumference (cm) | 107 (95–122) | 107 (97–122) | 107 (96–122) |
Waist-to-hip ratio | 0.94 (0.80–1.01) | 0.96 (0.89–1.03) | 0.94 (0.88–1.02) |
Body fat% | 35 (26–42) | 35 (29–40) | 35 (27–41) |
fP-Glucose (mmol/l) | 5.8 (5.3–6.7) | 5.7 (5.1–6.2) | 5.7 (5.2–6.5) |
HbA1c (%) | 5.8 (5.4–6.3) | 5.7 (5.3–6.1) | 5.7 (5.4–6.2) |
fS-Insulin (mU/l) | 9.0 (6.0–15.2) | 9.7 (6.0–15.7) | 9.3 (6.0–15.0) |
fS-C-peptide (nmol/l) | 0.90 (0.58–1.18) | 0.92 (0.64–1.18) | 0.94 (0.58–1.23) |
fS-Triglycerides (mmol/l) | 1.3 (1.0–1.9) | 1.4 (1.0–1.8) | 1.3 (1.0–1.9) |
fS-HDL cholesterol (mmol/l) | 1.3 (1.0–1.6) | 1.2 (1.1–1.6) | 1.3 (1.0–1.6) |
fS-LDL cholesterol (mmol/l) | 2.7 (2.1–3.3) | 2.8 (2.2–3.4) | 2.6 (2.1–3.4) |
