Table 1 Mixed-model results, only significant results are shown

From: The influence of the rs6295 gene polymorphism on serotonin-1A receptor distribution investigated with PET in patients with major depression applying machine learning

 

DF numerator

DF denominator

F-value

P-value

(A) Predictor

mixed model(all)

   

Genotype × ROI × Group

46

3404

1.482

0.005

 ROI

46

3404

641.663

<0.0001

(B) Predictor

mixed model (subgroups)

   

 Healthy subjects (n=62)

    

ROI

46

2622

855.433

<0.0001

 Patients (n=19)

    

ROI

46

690

149.134

<0.0001

ROI × Genotype

46

690

1.511

0.006

(C) ROI

post hoc analyses

   

 Fusiform gyrus

  

4.92

0.041

 Gyrus rectus

  

4.543

0.048

 Hippocampus

  

4.609

0.046

 Inferior occipital gyrus

  

4.718

0.044

 Lingual gyrus

  

5.849

0.027

 Parahippocampus

  

4.679

0.045

 Supplementory motor area

  

4.468

0.049

  1. Abbreviations: DF, degree of freedom; ROI, region of interest.
  2. For mixed model, only results withstanding correction for multiple testing are shown, post hoc analyses are uncorrected. (A) For all the subjects, as expected, ROI showed significant results. More importantly, a three-way interaction was found between groups, ROI and genotype that withstood correction for multiple testing. (B) Mixed-model results for patients and healthy subjects respectively, showing only significant results after correction for multiple testing. No effects of genotype were found in the healthy sample. Regarding the patients sample, an interaction effect of ROI and genotype could be demonstrated. (C) Post hoc analysis of variance (ANOVA) results for ROI, uncorrected. Seven regions were affected by rs6295 carrier status and effects were only present in the patients’ group of the sample.
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