Chemical modification of proteins

Chemical modification of proteins enables the development of proteins with novel functions and properties and has industrial and pharmacological applications. Modified proteins can exhibit improved drug-like properties, stability and enzymatic activity compared to their natural counterparts.

With this cross-journal Collection, the editors at Nature Communications, Communications Chemistry and Scientific Reports invite manuscripts that highlight advances in methods for chemical protein modification, including, but not limited to, chemical reaction development, improvements of existing methods, site-specific targeting of natural and unnatural amino acids, functionalization and bioconjugation. Nature Communications and Communications Chemistry will consider original Articles, Reviews and Perspectives. Scientific Reports will consider original Articles.